首页|牛蒡子化学成分和药理作用的研究进展及其质量标志物(Q-Marker)预测分析

牛蒡子化学成分和药理作用的研究进展及其质量标志物(Q-Marker)预测分析

Research Progress on Chemical Components and Pharmacological Action of Arctium lappa and Prediction Analysis of Its Quality Markers

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牛蒡子是我国传统中药材,具有抗炎、抗菌、抗癌、抗糖尿病等作用,主要含木脂素类、挥发油及脂肪酸类、萜类、酚酸类等化合物.本文在系统挖掘分析牛蒡子化学成分和药理作用的基础上,从植物亲缘关系、传统药性及有效性、网络药理学预测以及化学成分可测性等方面,对牛蒡子质量标志物进行预测分析,初步筛选牛蒡苷、牛蒡苷元、绿原酸、异绿原酸A、异绿原酸B和异绿原酸C等成分作为牛蒡子质量标志物.本文将为牛蒡子基于"质-效"相关性的现代质量评价模式的形成和进一步开发利用提供参考.
Arctium lappa is a traditional Chinese medicinal herb,mainly containing lignans,volatile oils,fatty acids,terpenoids,phenolic acids and other compounds,with anti-inflammatory,antibacte-rial,anticancer and anti-diabetic effects.In this paper,based on the systematic excavation and analysis of chemical composition and pharmacological effects of A.lappa,the quality markers of A.lappa were predicted and analyzed in terms of plant relatives,traditional medicinal properties,network pharmaco-logical prediction and chemical composition measurability.The components of burdock glycosides,burdock sapogenins,chlorogenic acid,isochlorogenic acid A,isochlorogenic acid B and isochlorogen-ic acid C were preliminarily screened as quality markers of A.lappa.It would provide reference for the formation of modern quality evaluation model of A.lappa based on quality-effect correlation and further development and utilization.

Arctium lappa L.Q-MarkerChemical componentsPharmacological effectPredic-tion and analysis

庞哲、何海、邢耀莹、赵宁、王露、邵晶

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甘肃中医药大学,甘肃 兰州 730000

西北中藏药协同创新中心,甘肃 兰州 730000

牛蒡子 质量标志物 化学成分 药理作用 预测分析

2024

中国野生植物资源
中华全国供销合作总社南京野生植物综合利用研究院

中国野生植物资源

影响因子:0.667
ISSN:1006-9690
年,卷(期):2024.43(z1)