The value of six tumor markers in preoperative diagnosis and prognostic evaluation of advanced serous ovarian cancer
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维普
万方数据
目的 探讨糖类抗原125(CA125)、癌胚抗原(CEA)、甲胎蛋白(AFP)、糖类抗原153(CA153)、糖类抗原199(CA199)、糖类抗原724(CA724)6种肿瘤标志物水平对上皮性卵巢癌(EOC)病理类型的诊断和预后评估的价值.方法 回顾性分析2010年1月至2022年5月石河子大学第一附属医院收治的131例EOC患者的术前肿瘤标志物及临床病理资料并进行随访,按照病理类型和肿瘤级别将患者分为高级别浆液性卵巢癌(HGSOC)组和其他组(黏液性癌、子宫内膜样癌、透明细胞癌、混合性癌).探究6种肿瘤标志物水平与EOC病理类型的相关性,通过绘制受试工作者特征(ROC)曲线并比较曲线下面积(AUC)探究6种肿瘤标志物单一及联合检测对EOC病理类型的诊断价值,K-M生存分析探究肿瘤标志物对患者预后的影响.结果 HGSOC组CA125、CA153水平显著高于其他病理类型组(Z=-2.571、-5.416,均P＜0.05);CA153对于HGSOC具有良好的诊断效能(AUC=0.777),CA125+CA153、CA153+AFP、CA153+CA199、CA153+CA724、CA153+ CEA 等联合检测诊断效能优于CA125和CA153单一检测(AUC=0.781、0.784、0.809、0.803、0.773),其中CA125、CA153、CA199三者联合检测具有最优的诊断效能(AUC=0.816,约登指数0.532);CA153和CA153+CA199升高预示患者无进展生存期(PFS)较差(均P＜0.05),CA153+CA199升高是患者复发的独立危险因素(P=0.02);CA153+CA199、CA125+CA153+CA199升高预示患者较差的OS(均P＜0.05).结论 HGSOC 患者血清 CA125、CA153 水平升高,CA153、CA153+CA199、CA125+CA153+CA199升高与患者不良预后相关,CA125、CA153、CA199三者联合检测具有最优诊断效能,可作为辅助诊断HGSOC和评估患者预后的潜在生物标志物.
Objective To explore the diagnostic and prognostic value of six tumor markers,namely carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA),alpha fetoprotein(AFP),carbohydrate antigen 153(CA153),carbohydrate antigen 199(CA199),and carbohydrate antigen 724(CA724),in the pathological types of epithelial ovarian cancer(EOC).Methods A retrospective analysis was conducted on the preoperative tumor markers and clinical pathological data of 131 EOC patients admitted to the First Affiliated Hospital of Shihezi University from January 2010 to May 2022,and follow-up was conducted.Patients were divided into high-grade serous ovarian cancer(HGSOC)group and other groups(mucinous cancer,endometrioid carcinoma,clear cell carcinoma,mixed carcinoma)according to pathological type and tumor grade.We investigated the correlation between the levels of six tumor markers and the pathological types of EOC.By drawing receiver operating characteristic(ROC)curves and comparing the area under the curve(AUC),we also investigated the diagnostic value of single and combined detection of six tumor markers for the pathological types of EOC.K-M survival analysis was used to explore the impact of tumor markers on patient prognosis.Results The levels of CA125 and CA153 in the HGSOC group were significantly higher than those in other pathological groups(Z=-2.571,-5.416,all P＜0.05);CA153 had good diagnostic performance for HGSOC(AUC=0.777),and the combined detection of CA125+CA153,CA153+AFP,CA153+CA199,CA153+CA724,CA153+CE had better diagnostic performance than the single detection of CA125 and CA153(AUC=0.781,0.784,0.809,0.803,0.773).Among them,the combined detection of CA125,CA153,and CA199 had the best diagnostic performance(AUC=0.816,Youden's index 0.532);the elevated levels of CA153 and CA153+CA199 indicated poor recurrence free survival(PFS)in patients(all P＜0.05),while the elevated levels of CA153+CA199 was an independent risk factor for recurrence in patients(P=0.022);the elevated levels of CA153+CA199 and CA125+CA153+CA199 indicated poorer OS in patients(all P＜0.05).Conclusions The serum levels of CA125 and CA153 are elevated in patients with HGSOC.Elevated levels of CA153,CA153+CA199,and CA125+CA153+CA199 are associated with poor prognosis in patients.The combined detection of CA125,CA1 53,and CA199 has the best diagnostic efficacy and can serve as a potential biomarker for assisting in the diagnosis of HGSOC and evaluating patient prognosis.
维普
万方数据
