Objective To explore the therapeutic effect of dual microcatheter technology on acute intracranial wide necked aneurysms and its impact on serum levels of matrix metalloproteinase-9(MMP-9),neuron specific enolase(NSE),and central nervous system specific protein(S100β).Methods A prospective study was conducted on 80 patients with acute intracranial wide neck aneurysms admitted to the Affiliated Suzhou Hospital of Anhui Medical University from January 2020 to March 2023.They were randomly divided into an observation group and a control group,with 40 cases in each group,using a random number table method.The control group patients were treated with stent assisted spring coil intervention embolization,while the observation group patients were treated with dual microcatheter technology intravascular intervention embolization.We compared the perioperative conditions of two groups,including changes in serum MMP-9,NSE,and S100β,as well as short-term prognosis,changes in the National Institutes of Health Stroke Scale(NIHSS)score,Barthel Index(BI)score,and incidence of complications.Results The observation group had shorter surgical and hospital stay than the control group,and the difference was statistically significant(all P＜0.05);At 7 days after surgery,the serum levels of MMP-9,NSE,and S100β in the observation group were lower than those in the control group,and the differences were statistically significant(all P＜0.05);The short-term good prognosis rate of the observation group was 55.00％(22/40),significantly higher than the control group's 32.50％(13/40),and the difference was statistically significant(all P＜0.05);At one month after surgery,the NIHSS score in the observation group was lower than that in the control group,while the BI score was higher than that in the control group,with statistically significant differences(all P＜0.05);There was no statistically significant difference in the total incidence of postoperative complications between the two groups(P＞0.05).Conclusions The dual microcatheter technique has a significant therapeutic effect on acute intracranial wide neck aneurysms,reducing the increase in serum MMP-9,NSE,and S100β levels after surgery,promoting postoperative recovery,and is worthy of clinical promotion.
Intracranial aneurysmEmbolization,therapeuticMatrix metalloproteinase 9Neuron specific alcoholaseS100 calcium binding protein beta subunit
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