Dental pulp stem cells(DPSC)are pluripotent stem cells with high differentiation potential isolated from dental pulp.Using DPSC for vascular regeneration may be a good option.Hypoxia inducible factor-1α(HIF-1α)is an upstream gene of vascular endothelial growth factor(VEGF),and the small ubiquitin like protease 1(SENP1)can reverse the small ubiquitin like(SUMO)modification of HIF-1α.Through the regulation of SENP1/HIF-1α,good vascular regeneration characteristics have been demonstrated in many in vitro and in vivo experiments.The SENP1/HIF-1α signaling axis has varying degrees of promoting and inhibiting effects on many solid tumors.Although there is relatively little literature on therole ofthe SENP1/HIF-1α signaling axis in dental pulp stem cells,it can be determined that SENP1/HIF-1α plays an important role in the angiogenesis of dental pulp stem cells.This article will elucidate the SENP1/HIF-1α signaling pathway and its mechanism of promoting vascular differentiation of DPSC.
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