摘要
目的 探讨中医方剂溃结灌肠液联合西医对溃疡性结肠炎患者的治疗效果.方法 采取临床前瞻性随机试验,将十堰市人民医院2018年1月至2022年12月收治的107例溃疡性结肠炎患者纳入研究,按随机数字表法分为联合组(54例)和对照组(53例),两组患者均采用相同的基础治疗方案,联合组在此基础上加用中医方剂溃结灌肠液治疗,两组患者均连续治疗4周,观察两组患者治疗前后的血清炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、单核细胞趋化因子-1(MCP-1)]、Mayo评分、内镜黏膜评分、中医证候评分、临床治疗效果差异.结果 治疗后两组患者的血清TNF-α、IL-6、MCP-1水平均较治疗前下降,IL-10水平均上升,且联合组上述炎症因子水平变化更明显,差异均有统计学意义(均P＜0.05).治疗后两组患者Mayo评分、内镜黏膜评分均较治疗前下降(均P＜0.05),且联合组患者的Mayo评分、内镜黏膜评分低于对照组(均P＜0.05).治疗后,两组中医证候评分均较治疗前下降(均P＜0.05),且联合组患者的腹泻、腹痛、脓血便、里急后重、肛门灼热评分低于对照组,差异均有统计学意义(均P＜0.05).两组患者均连续治疗4周,联合组患者的总体疗效分布优于对照组(Z=-2.274,P=0.023).结论 中医方剂溃结灌肠液联合西医治疗溃疡性结肠炎患者能更有效地减轻患者炎症反应程度,缓解临床症状,提高临床治疗效果.
Abstract
Objective To explore the therapeutic effect of traditional Chinese medicine formula Kuijie enema combined with Western medicine on patients with ulcerative colitis.Methods A clinical prospective randomized trial was conducted,and 107 patients with ulcerative colitis admitted to the Shiyan People's Hospital from January 2018 to December 2022 were included in the study.They were randomly divided into a combination group of 54 cases and a control group of 53 cases using a random number table method.Both groups of patients received the same basic treatment plan,and the combination group was treated with traditional Chinese medicine formula for ulcerative colitis enema on this basis.Both groups of patients were treated continuously for 4 weeks,We observed the differences in serum inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10),monocyte chemokine 1(MCP1)],Mayo score,endoscopic mucosal score,traditional Chinese medicine symptom score,and clinical treatment efficacy between two groups of patients before and after treatment.Results After treatment,the serum levels of TNF-α,IL-6,and MCP1 in the two groups were lower than those before treatment,and IL-10 was higher(all P＜0.05),and the changes of the above inflammatory factors were more obvious in the combined group,with statistically significant differences(all P＜0.05).After treatment,the Mayo score and endoscopic mucosal score of both groups of patients decreased compared to before treatment(all P＜0.05),and the Mayo score and endoscopic mucosal score of patients in the combination group were lower than those in the control group(all P＜0.05).After treatment,the traditional Chinese medicine syndrome scores of both groups decreased compared to before treatment(all P＜0.05),and the combined group patients had lower scores for diarrhea,abdominal pain,pus and bloody stools,urgency and weight,and anal burning than the control group,with statistical significance(all P＜0.05).Both groups of patients were treated continuously for 4 weeks,and the overall efficacy distribution of the combination group was better than that of the control group(Z=-2.274,P=0.023).Conclusions The combination of traditional Chinese medicine formula Kuijie enema liquid and Western medicine can more effectively reduce the degree of inflammation in patients with ulcerative colitis,alleviate clinical symptoms,and improve clinical treatment effectiveness.
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