免疫球蛋白A肾病治疗新进展
New progress in the treatment of immunoglobulin A nephropathy
石尧童 1杨婷 2刘晶3
作者信息
- 1. 江苏大学鼓楼临床医学院,镇江 212000
- 2. 南京大学医学院附属鼓楼医院药学部,南京 210000
- 3. 南京大学医学院附属鼓楼医院肾内科,南京 210000
- 折叠
摘要
免疫球蛋白A肾病(IgAN)是世界范围内最常见的原发性肾小球肾炎,病理表现以IgA在肾小球系膜区沉积为主而被定义.目前IgAN的发病机制尚不明确,一直缺乏特异的公认治疗方案.近年来,国内外不少研究者针对其发病机制中的重要途径及关键分子进行研究,旨在探索出新的治疗药物.本篇综述主要总结IgAN治疗方面的最新进展,包括已经被证明对IgAN有效的药物及正在进行临床研究评估的药物.
Abstract
Immunoglobulin A nephropathy(IgAN)is the most common primary glomerulonephritis worldwide,characterized by the deposition of IgA in the mesangial area of the glomerulus.At present,the pathogenesis of IgAN is not yet clear,and there has been a lack of specific and recognized treatment plans.In recent years,many domestic and foreign researchers have conducted research on important pathways and key molecules in its pathogenesis,aiming to explore new therapeutic drugs.This review mainly summarizes the latest progress in the treatment of IgAN,including drugs that have been proven effective against IgAN and drugs that are currently being evaluated in clinical studies.
关键词
肾小球肾炎,IGA/糖皮质激素/免疫抑制剂/补体灭活剂Key words
Glomerulonephritis,IGA/Glucocorticoids/Immunosuppressive agents/Complement inactivating agents引用本文复制引用
基金项目
江苏省研究型医院学会精益化用药-石药专项科研基金项目(JY202013)
出版年
2024
NETL
NSTL
万方数据