基于门静脉高压病因转变与功能状态调整治疗策略
Treatment strategies based on the etiology transformation and functional status adjustment of portal hypertension
黄晓铨 1陈世耀1
作者信息
- 1. 复旦大学附属中山医院消化科,上海 200032;复旦大学循证医学中心,上海 200032
- 折叠
摘要
近年来门静脉高压的病因发生了许多变化.除了需关注病毒性、酒精性肝病,肥胖、高脂与糖尿病人群外,各种药物尤其是铂类药物化疗后、骨髓增殖性疾病、自身免疫性肝病患者等都需要列入高危筛查人群.病因的改变带来复杂的病理生理学状态,我们需要通过全面评估,了解既往病史,完善门脉血管CT、肝脏弹性成像、胃镜等检查,明确病因,为患者选择个体化治疗方案.通过技术创新,提高内镜治疗疗效,结合人工智能、大数据和多组学等新理念,获得更准确的门静脉压力与临床特征预测,细化风险分层,为临床的诊疗做出更精准的个体化决策.
Abstract
In recent years,the etiology of portal hypertension has undergone many changes.In addition to the focus on viral and alcoholic liver diseases,obesity,hyperlipidemia and diabetes patients,all kinds of drugs,especially after chemotherapy with platinum drugs,bone marrow proliferative diseases,autoimmune liver disease patients,need to be included in the high-risk screening population.The change in etiology brings about complex pathological and physiological states.We need to conduct a comprehensive evaluation,understand past medical history,improve portal vein computed tomography(CT),liver elastography,gastroscopy and other examinations,clarify the etiology,and choose personalized treatment plans for patients.Through technological innovation,we aim to improve the efficacy of endoscopic therapy,combined with new concepts such as artificial intelligence,big data,and multi omics,so as to obtain more accurate prediction of portal vein pressure and clinical characteristics,refine risk stratification,and make more accurate personalized decisions for clinical diagnosis and treatment.
关键词
高血压,门静脉/食管和胃静脉曲张/内窥镜检查Key words
Hypertension,portal/Esophageal and gastric varices/Endoscopy引用本文复制引用
基金项目
上海市科委医学创新研究专项(22Y11907400)
出版年
2024
NETL
NSTL
万方数据