摘要
目的 探究2型糖尿病(T2DM)患者蛋白尿的影响因素及其预测价值.方法 选取2022年1月至2023年5月阜阳市中医医院200例T2DM患者,依据尿白蛋白与肌酐比值(UACR)分为蛋白尿阴性组、蛋白尿阳性组.比较两组患者基本特征资料、实验室检查资料,单因素及多因素分析T2DM患者出现蛋白尿的独立危险因素,分析独立危险因素对T2DM患者出现蛋白尿的预测价值.结果 单因素分析显示,蛋白尿阳性组T2DM病程、收缩压、总胆固醇、低密度脂蛋白胆固醇、血肌酐、尿酸、空腹血糖、糖化血红蛋白水平与体重指数(BMI)≥25 kg/m2、维生素D缺乏比例均大于蛋白尿阴性组(均P＜0.05).多因素logistic回归分析显示,BMI(OR=1.451)、T2DM病程(OR=1.462)、收缩压(OR=1.078)、尿酸(OR=1.005)、空腹血糖(OR=1.195)、维生素 D 缺乏(OR=3.391)均为T2DM患者出现蛋白尿的独立危险因素(均P＜0.05).受试者工作特征(ROC)曲线显示,BMI、T2DM病程、收缩压、尿酸、空腹血糖、维生素D缺乏均对T2DM患者出现蛋白尿具有一定预测效能.结论 BMI、T2DM病程、收缩压、尿酸、空腹血糖、维生素D缺乏与T2DM患者蛋白尿独立相关,且均对出现蛋白尿具一定预测价值,早期干预相关因素有望延缓糖尿病肾病发展.
Abstract
Objective To explore the influencing factors and predictive value of proteinuria in patients with type 2 diabetes(T2DM).Methods A total of 200 T2DM patients from the Fuyang Traditional Chinese Medicine Hospital from January 2022 to May 2023 were selected and divided into proteinuria negative group and proteinuria positive group based on the urinary albumin to creatinine ratio(UACR).We compared the basic characteristic data and laboratory examination data of two groups of patients,and analyzed the independent risk factors for proteinuria in T2DM patients through univariate and multivariate analysis.We also analyzed the predictive value of independent risk factors for proteinuria in T2DM patients.Results Univariate analysis showed that the duration of T2DM,systolic blood pressure,total cholesterol,low-density lipoprotein cholesterol,blood creatinine,uric acid,fasting blood glucose,glycated hemoglobin levels,body mass index(BMI)≥25 kg/m2,and the proportion of vitamin D deficiency in the proteinuria positive group were all higher than those in the proteinuria negative group(all P＜0.05).Multivariate logistic regression analysis showed that BMI(OR=1.451),duration of T2DM(OR=1.462),systolic blood pressure(OR=1.078),uric acid(OR=1.005),fasting blood glucose(OR=1.195),and vitamin D deficiency(OR=3.391)were all independent risk factors for proteinuria in T2DM patients(all P＜0.05).The receiver operating characteristic(ROC)curve shows that BMI,duration of T2DM,systolic blood pressure,uric acid,fasting blood glucose,and vitamin D deficiency all have certain predictive power for proteinuria in T2DM patients.Conclusions BMI,T2DM course,systolic blood pressure,uric acid,fasting blood glucose and vitamin D deficiency are independently related to proteinuria in T2DM patients,and all of them have certain predictive value for the occurrence of proteinuria.Early intervention of related factors is expected to delay the development of diabetes nephropathy.
NETL
NSTL
万方数据