microRNA在子宫内膜异位症炎症和纤维化中的作用机制研究进展
Research progress on the mechanism of micro-RNA in inflammation and fibrosis of endometriosis
杨惠 1喻翠萍 1李冰冰1
作者信息
- 1. 济宁医学院中西医结合学院,济宁 272000
- 折叠
摘要
子宫内膜异位症(EM)是育龄期女性常见的妇科疾病,其发病机制目前尚未完全阐明.EM是一种慢性炎症性反应,长期的炎症渗出又会导致纤维化粘连的产生.炎症反应和纤维化形成是EM的主要病理特征,也是导致疼痛和不孕的主要原因.研究显示在EM中存在某些差异表达的微小RNA(microRNA,miRNA)参与炎症和纤维化过程,并发挥重要调节作用.本文就miRNA在EM炎症和纤维化病理过程中的作用机制进行综述,旨在为探究EM发病机制和诊疗寻找新的方向和思路.
Abstract
Endometriosis(EM)is a common gynecological disease in women of childbearing age,and its pathogenesis is currently not fully understood.EM are a chronic inflammatory response,and long-term inflammatory exudation can lead to the production of fibrotic adhesions.Inflammatory response and fibrosis formation are the main pathological features of EM,as well as the main causes of pain and infertility.Research has shown that there are certain differentially expressed microRNAs(miRNAs)in EM that participate in inflammation and fibrosis processes and play important regulatory roles.This article reviews the mechanism of miRNA in the inflammatory and fibrotic pathological processes of EM,aiming to find new directions and ideas for exploring the pathogenesis and diagnosis and treatment of EM.
关键词
微RNAs/子宫内膜异位症/炎症/纤维化Key words
MicroRNAs/Endometriosis/Inflammation/Fibrosis引用本文复制引用
基金项目
国家自然科学基金(82104920)
山东省自然科学基金(ZR2021QH129)
山东省中医药科技项目(2021Q066)
山东省中医药重点实验室项目(鲁卫涵[2022]331号)
出版年
2024
NETL
NSTL
万方数据