回肠代输尿管术后黏液相关并发症的研究进展
Research progress on mucus related complications after ileal ureteral replacement surgery
石飞 1杨登浩 1唐文 1谢志飞 1刘明文 1赵泽驹1
作者信息
- 1. 遵义医科大学附属医院泌尿外科,遵义 563000
- 折叠
摘要
长段输尿管缺损的修复重建是泌尿外科医师面临的一类技术难题.回肠代输尿管是目前治疗长段输尿管缺损的主要手术方法,在回肠代输尿管术后作为回肠黏液主要功能成分的黏蛋白2(MUC2)和黏蛋白3(MUC3)继续高表达.此外,MUC2基因在术后的表达不仅仅限于杯状细胞中,甚至可表达于回肠吸收细胞中,最终导致黏蛋白的大量合成和黏液的大量分泌.黏液可导致梗阻、感染等多种并发症,严重影响治疗效果.目前业界已尝试多种方法以减少回肠代输尿管术后黏液分泌及相关并发症的发生,例如通过裁剪回肠减少黏膜面积、通过黏膜剥除减少黏液的产生等,取得了一定的效果.本文就回肠代输尿管术后黏液相关并发症的类型、分子机制、解决方案等研究进展作一综述.
Abstract
The repair and reconstruction of long ureteral defects is a technical challenge faced by urologists.The ileal ureter replacement is currently the main surgical method for treating long segment ureteral defects.After the ileal ureter replacement surgery,mucin 2(MUC2)and mucin 3(MUC3),which are the main functional components of ileal mucus,continue to be strongly expressed.In addition,the expression of MUC2 gene after surgery is not limited to goblet cells,but can even be expressed in absorption cells of the ileum,ultimately leading to a large amount of mucin synthesis and mucus secretion.Mucus can cause many complications such as obstruction and infection,seriously affecting the treatment effect.At present,the industry has tried various methods to reduce the secretion of mucus and related complications after ileal ureteral replacement surgery,such as cutting the ileum to reduce mucosal area and mucosal exfoliation to reduce mucus production,and has achieved certain results.This article provides a review of research progress on the types,molecular mechanisms,and solutions of mucus related complications after ileal ureteral replacement surgery.
关键词
输尿管疾病/回肠代输尿管术/手术后并发症/黏液Key words
Ureteral diseases/Ileal ureter/Postoperative complications/Mucus引用本文复制引用
基金项目
遵义市科技计划(遵市科合HZ字2020229号)
出版年
2024
NETL
NSTL
万方数据