结直肠癌患者血清中人附睾蛋白4的表达及其与复发转移的关系
The expression of serum human epididymal protein 4 in colorectal cancer patients and its relationship with recurrence and metastasis
王韬 1王一飞 1李磊 1田宝华 1李璐 1费建东1
作者信息
- 1. 河北北方学院附属第一医院普外科,张家口 075000
- 折叠
摘要
目的 探讨结直肠癌患者血清中人附睾蛋白4(HE4)的表达情况及其与复发转移的关系.方法 前瞻性收集2018年1月至12月河北北方学院附属第一医院收治的100例结直肠癌患者作为观察组,50例健康志愿者作为对照组,结直肠癌患者均行结直肠癌根治性手术,术前留血清样本.采用酶联免疫吸附试验(ELISA)检测血清HE4水平,分析观察组血清HE4水平与其临床病理特征的关系,分析观察组术前血清HE4水平与结直肠癌术后复发转移的关系,COX比例风险模型分析结直肠癌术后复发转移的影响因素,绘制受试者工作特征(ROC)曲线,分析观察组术前血清HE4水平对结直肠癌术后复发转移的预测价值.结果 观察组血清HE4水平明显高于对照组,差异有统计学意义(P＜0.05).低分化患者血清HE4水平高于中、高分化患者,淋巴结转移患者血清HE4水平高于无淋巴结转移患者(均P＜0.05).低血清HE4水平患者结直肠癌术后复发转移率明显低于高水平患者(P＜0.05),COX比例风险模型显示分化程度、淋巴结转移、血清HE4水平是结直肠癌术后复发、转移的影响因素(均P＜0.05).术前血清HE4水平预测结直肠癌术后复发转移的灵敏度为72.7％、特异度为73.1％.结论 结直肠癌患者血清HE4高表达,其与结直肠癌术后复发转移密切相关.
Abstract
Objective To investigate the expression of serum human epididymal protein 4(HE4)in colorectal cancer patients and its relationship with recurrence and metastasis.Methods A prospective study was conducted to collect 100 patients with colorectal cancer admitted to the First Affiliated Hospital of Hebei North University from January to December 2018 as the observation group,and 50 healthy volunteers as the control group.All patients underwent radical surgery for colorectal cancer,and serum samples were collected before surgery.Enzyme linked immunosorbent assay(ELISA)was used to detect serum HE4 levels,and the relationship between serum HE4 levels and clinical pathological characteristics in the observation group was analyzed.The relationship between preoperative serum HE4 levels and postoperative recurrence and metastasis of colorectal cancer in the observation group was also analyzed.The COX proportional risk model was used to analyze the influencing factors of postoperative recurrence and metastasis of colorectal cancer,and the receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of preoperative serum HE4 levels in the observation group for postoperative recurrence and metastasis of colorectal cancer.Results The serum HE4 level in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P＜0.05).The serum HE4 levels in patients with low differentiation were higher than those in patients with medium and high differentiation,while those with lymph node metastasis had higher serum HE4 levels than those without lymph node metastasis(all P＜0.05).The postoperative recurrence and metastasis rate of colorectal cancer in patients with low serum HE4 levels was significantly lower than that in patients with high levels(P＜0.05).The COX proportional risk model showed that differentiation degree,lymph node metastasis,and serum HE4 levels were influencing factors for postoperative recurrence and metastasis of colorectal cancer(all P＜0.05).The sensitivity and specificity of preoperative serum HE4 levels in predicting postoperative recurrence and metastasis of colorectal cancer were 72.7％and 73.1％,respectively.Conclusions Serum HE4 is highly expressed in colorectal cancer and is closely related to postoperative recurrence and metastasis of colorectal cancer.
关键词
结直肠肿瘤/人附睾蛋白4/肿瘤复发/肿瘤转移Key words
Colorectal neoplasms/Human epididymis protein 4/Neoplasm recurrence/Neoplasm metastasis引用本文复制引用
基金项目
河北省医学科学研究课题(2020)(20200522)
出版年
2024
NETL
NSTL
万方数据