Application of automatic functional imaging technology in evaluating left ventricular and left atrial damage in patients with alcoholic cardiomyopathy
Objective To explore the application and clinical significance of Automatic Functional Imaging(AFI)technology in evaluating left ventricular and left atrial damage in patients with alcoholic cardiomyopathy.Methods A total of 120 patients with alcoholic cardiomyopathy who visited the Affiliated Hospital of Jining Medical University from April 2021 to March 2023 were selected,including 40 patients with mild,moderate,and severe alcohol consumption each.At the same time,40 healthy volunteers who did not drink alcohol were selected as controls.All subjects underwent ultrasound examination,and the differences in two-dimensional ultrasound and AFI parameters among the groups were analyzed.Pearson correlation analysis was used to evaluate the correlation between AFI parameters and two-dimensional ultrasound parameters.The diagnostic value of global long axis peak systolic strain(GLPS)of the left ventricle in alcoholic cardiomyopathy was analyzed using receiver operating characteristic(ROC)curves.Results The left ventricular end diastolic diameter(LVDd),left ventricular end systolic diameter(LVDS),end diastolic interventricular septal thickness(IVSTd),end diastolic left ventricular posterior wall thickness(PWTd),left atrial minimum volume(LAVmin),left atrial maximum volume(LAVmax),and left atrial active pre systolic volume(LAVp)in the severe group were significantly larger than those in the control group,mild group,and moderate group(all P＜0.05),while the left ventricular ejection fraction(LVEF)and the ratio of E peak velocity to A peak velocity(E/A)were significantly smaller than those in the control group,mild group,and moderate group(all P＜0.05);The left ventricular end diastolic volume(LVEDV),left ventricular end systolic volume(LVESV),left ventricular mass index(LVMI),LAVmin,LAVmax,and LAVp in the moderate and severe groups were significantly higher than those in the control and mild groups(all P＜0.05);There was no statistically significant difference in LVDd,LVDS,IVSTd,PWTd,and LVEF among the control group,mild group,and moderate group(all P＞0.05).The GLPS levels in the mild,moderate,and severe groups were significantly higher than those in the control group(all P＜0.05),with the severe group having significantly higher GLPS levels than the mild and moderate groups(P＜0.05);There was no statistically significant difference in peak strain dispersion(PSD)among the control group,mild group,moderate group,and severe group(all P＞0.05).GLPS was negatively correlated with LVEF(r=-0.441,P＜0.05),while GLPS was positively correlated with LVMI(r=0.504,P＜0.05).The area under the ROC curve for diagnosing alcoholic cardiomyopathy with GLPS was 0.912(95％CI:0.869-0.955,P＜0.05),with a cutoff value of-20.16,sensitivity and specificity of 76.70％and 95.00％,respectively.Conclusions The mechanical properties of the left ventricle and left atrium in patients with alcoholic cardiomyopathy are significantly altered,and AFI parameters have certain application value in the diagnosis of alcoholic cardiomyopathy.
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