The effects of intravenous infusion of remifentanil combined with esketamine on blood glucose during gastrointestinal surgery
Objective To explore the effect of intravenous infusion of remifentanil and remifentanil combined with esketamine on blood glucose during gastrointestinal surgery.Methods A prospective selection of 160 patients who underwent elective gastrointestinal surgery at Nanjing Hospital and the Fourth Affiliated Hospital of Nanjing Medical University from July 2023 to October 2023 was conducted.The patients were randomly divided into a control group(remifentanil group)and an observation group(remifentanil combined with esketamine group)using a random number table method,with 80 patients in each group.Both groups were anesthetized with remifentanil.The observation group received intravenous injection of 0.5 mg/kg of esketamine during anesthesia induction,followed by maintenance at a dose of 0.12 mg/(kg·h)until the sutured skin.The control group received an equal amount of physiological saline,and the anesthesia induction and maintenance plans were the same for both groups.Two groups of intraoperative and postoperative blood glucose and insulin usage,as well as intraoperative atropine and ephedrine usage,anesthesia time,extubation time,and post anesthesia care unit(PACU)retention time were recorded.Visual Analog Scale(VAS)scores were also recorded at 6,12,and 24 hours post surgery,as well as the incidence of complications.Results The intraoperative blood glucose levels in the observation group were lower than those in the control group,and the blood glucose levels at 6,12,and 24 hours postoperatively were higher than those before and during surgery.The blood glucose levels at 6 and 12 hours postoperatively were higher than those at 24 hours postoperatively,and the differences were statistically significant(all P＜0.05).The proportion of patients with intraoperative and postoperative blood glucose＞7 mmol/L in the observation group was significantly lower than that in the control group,and the difference was statistically significant(all P＜0.05).There was no statistically significant difference in the proportion of insulin use between the two groups during surgery(P＞0.05).The postoperative insulin use in both groups was significantly higher than that during surgery,and the difference was statistically significant(all P＜0.05).There was no statistically significant difference in anesthesia time between the two groups of patients(P＞0.05).The observation group had shorter extubation time and PACU retention time than the control group,and the difference was statistically significant(all P＜0.05).The incidence of intraoperative heart rate(HR)＜60 beats/min and mean arterial pressure(MAP)＜60 mmHg in the observation group were significantly lower than those in the control group,and the differences were statistically significant(all P＜0.05).The maintenance dose of propofol and remifentanil in the observation group were both lower than those in the control group,and the difference was statistically significant(all P＜0.05).The proportion of additional remifentanil,the dosage of hydroxycodone used within 24 hours,and the proportion of atropine and ephedrine used in the observation group were all lower than those in the control group,and the differences were statistically significant(all P＜0.05).The VAS scores of the observation group at rest and activity 12 hours after surgery were significantly lower than those of the control group,with a statistically significant difference(P＜0.05).There was no statistically significant difference in VAS scores between the two groups at other time points(all P＞0.05).Conclusions Intraoperative infusion of 0.1-0.4 μ g/(kg·min)remifentanil combined with 0.12 mg/(kg·h)esketamine can inhibit intraoperative stress induced blood glucose elevation,maintain good heart rate and mean arterial pressure,and prevent postoperative remifentanil induced hyperalgesia.
NETL
NSTL
万方数据
