Expression and clinical significance of serum Hsa_circ_0089761 in cervical cancer patients
Objective To explore the expression level and clinical significance of serum Hsa_circ_0089761 in patients with cervical cancer.Methods A total of 107 cervical cancer patients,80 cervical intraepithelial neoplasia(CIN)patients,and 60 normal control group were selected and analyzed from January 2021 to March 2023 at the Ninth Affiliated People's Hospital of Shanghai Jiao Tong University School of Medicine.We compared the levels of serum Hsa_circ_0089761,squamous cell carcinoma antigen(SCCA),and carcinoembryonic antigen(CEA)among different groups,and analyzed the relationship between the expression level of serum Hsa_circ_0089761 and the clinical and pathological characteristics of cervical cancer.The receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of serum Hsa_circ_0089761,SCCA,and CEA levels for cervical cancer.Pearson correlation analysis was used to evaluate the correlation between serum Hsa_circ_0089761 expression levels and SCCA and CEA in cervical cancer patients.Results The expression levels of serum Hsa_circ_0089761[(2.96±0.95)vs(1.83±0.74),(0.92±0.41)],SCCA[(9.63±1.84)ng/ml vs(2.28±0.65)ng/ml,(1.30±0.27)ng/ml],and CEA[(6.47±2.20)ng/ml vs(1.61±0.57)ng/ml,(1.15±0.12)ng/ml]in the cervical cancer group were significantly higher than those in the CIN group and the control group(all P＜0.001),and the serum Hsa_circ_0089761 expression levels in the CIN group were significantly higher than those in the control group(P＜0.001).Cervical cancer patients in stages Ⅲ-Ⅳ,with low differentiation,lymph node metastasis,infiltration depth ≥1/2 of the muscle layer,positive SCCA,and positive CEA had significantly higher levels of serum Hsa_circ_0089761 expression(all P＜0.05).The ROC curve analysis showed that the specificity of diagnosing cervical cancer was highest(85.00％)for Hsa_circ_0089761 ≥2.25,and the area under the ROC curve(AUC)for diagnosing cervical cancer in combination with SCCA was highest(0.932,95％CI:0.874-0.993),with the highest accuracy(89.30％).The sensitivity of the combination of Hsa_circ_0089761+SCCA+CEA in diagnosing cervical cancer was highest(96.26％).The correlation analysis results showed that the serum Hsa_circ_0089761 expression levels in cervical cancer patients were positively correlated with SCCA(r=0.775,P＜0.001)and CEA(r=0.613,P＜0.001).Conclusions The expression level of serum Hsa_circ_0089761 in cervical cancer patients is significantly increased,which is related to clinical and pathological characteristics.The combination of Hsa_circ_0089761 and SCCA detection has high value in the diagnosis of cervical cancer.
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