动静脉内瘘功能障碍机制的研究进展
Advances in the mechanism of arteriovenous endovascular fistula dysfunction
黄文彤 1隋晓露 2谢婷妃 2许云鹏 2张燕子 2张艾莎 2陈家辉 1钟晓玲 1陈继红1
作者信息
- 1. 广东医科大学第一临床医学院,湛江 524023
- 2. 深圳市宝安区人民医院肾内科,深圳 518000
- 折叠
摘要
内瘘血管的狭窄和栓塞直接影响维持性血液透析患者的临床治疗效果,内瘘狭窄的机制成为近年来的研究热点.既往研究主要集中于血管壁的血流动力学、病理生理学,关于分子生物学及其相关的信号通路等方面的研究较少.本文将综述国内外动静脉内瘘(AVF)血管通路的血流动力学及AVF功能障碍的病理生理机制、分子生物学、多种信号通路改变的最新进展,旨在为AVF功能障碍相关研究提供参考.
Abstract
The stenosis and embolization of internal fistula vessels directly affect the clinical treatment effect of maintenance hemodialysis patients,and the study of the mechanism of internal fistula stenosis has become a research hotspot in recent years.Previous studies mainly focused on the hemodynamics and pathophysiology of blood vessel wall,and there were few studies on molecular biology and its related signaling pathways.This paper reviews the hemodynamics of the vascular pathway of internal arteriovenous fistula(AVF),the pathophysiological mechanism,molecular biology,and changes in various signaling pathways of AVF dysfunction at home and abroad,in order to provide references for the study of AVF dysfunction.
关键词
血液透析/动静脉内瘘/血管内膜/血流动力学Key words
Hemodialysis/Arteriovenous fistula/Tunica intima/Hemodynamics引用本文复制引用
出版年
2024
NETL
NSTL
万方数据