Objective To retrospectively analyze and study the clinical characteristics,imaging manifestations,laboratory tests,electroencephalography(EEG)results,immunotherapy efficacy,and prognosis of 48 patients with autoimmune encephalitis(AE)in the Hengyang area.Methods Clinical data of 48 AE patients admitted to the First Affiliated Hospital,the Second Affiliated Hospital,and the Affiliated Nanhua Hospital,University of South China from January 2020 to April 2024 were collected.Retrospective analysis was conducted on age,gender,prodromal symptoms,initial symptoms,main clinical manifestations,cranial magnetic resonance imaging(MRI),electroencephalogram,cerebrospinal fluid routine biochemistry,serum and cerebrospinal fluid antibody detection results,and immunotherapy efficacy.Results Among the 48 patients,there were 24 males and 24 females,with a median age of onset of 50 years.In terms of clinical manifestations,abnormal mental behavior is the most common initial symptom,accounting for 37.5％(18/48);The next was epileptic seizures,accounting for 35.4％(17/48);16.7％(8/48)of patients experienced cognitive impairment;Rare initial symptoms included movement disorders,blurred vision,and loss of consciousness.In terms of neuroimaging,47.9％(23/48)of patients had abnormal signals on cranial MRI,including 47.8％(11/23)of abnormal signals in the temporal lobe or hippocampus,39.1％(9/23)in the frontal and parietal regions,17.4％(4/23)in the occipital region,13.0％(3/23)in the basal ganglia,and 8.7％(2/23)in the thalamus.In terms of EEG,33.3％(16/48)of patients showed varying degrees of EEG abnormalities,manifested as diffuse slow waves,focal slow waves,epileptic like discharges,or increased fast waves.In terms of laboratory testing,60.4％(29/48)of patients had routine biochemical abnormalities in cerebrospinal fluid,including elevated white blood cell count(＞10 × 106 cells/L)in 33.3％(16/48),elevated protein(＞0.45 g/L)in 37.5％(18/48),and elevated IgG in 33.3％(16/48).In terms of antibody testing,27 cases were positive for antibodies,including 17 cases of N-methyl-D-aspartate receptor(NMDAR)antibody,3 cases of anti-contactin associated protein 2(CASPR2)antibody,3 cases of anti-metabotropic glutamate receptors 5(mGluR5)antibody,2 cases of anti-dipeptidyl-peptidase-like protein(DPPX)antibody,1 case of anti-GlyR antibody,and 1 case of anti-GAD65 antibody.In terms of treatment,33 patients received immunotherapy on the basis of symptomatic treatment,and 13 of them showed improvement in clinical symptoms.Conclusions The clinical manifestations of AE patients are highly heterogeneous,with typical initial clinical manifestations including mental abnormalities,epileptic seizures,cognitive and motor disorders.Neuroimaging changes are mainly in the temporal lobe or hippocampus,and antibody detection can timely confirm the diagnosis of AE.Early immunotherapy is the key to improving the prognosis of AE.
维普
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