Anti N-methyl-D-aspartate receptor(NMDAR)encephalitis is a rare autoimmune encephalitis,and its diverse etiology and clinical manifestations have attracted attention.However,the etiology and pathogenesis of anti NMDAR encephalitis are not yet fully understood,and its diagnosis and treatment still have certain limitations.This review mainly explores the environmental genetic factors that drive the occurrence of diseases and the biological indicators that are beneficial for diagnosis.It also elaborates on the current immune regulation and emerging treatment pathways,points out potential targeted interventions,and looks forward to the challenges and future development directions they face.