Objective To systematically evaluate the correlation between chronic periodontitis and postmenopausal osteoporosis(PMOP).Methods Electronic searches were conducted on Cochrane Library,Pubmed,Embase,Ovid,CNKI,CBM,VIP,and WF databases to collect research literature on the correlation between chronic periodontitis and PMOP.The Newcastle Ottawa Scale(NOS)criteria were used to evaluate the quality of the included literature,and RevMan 5.3 software was used for meta-analysis.The outcome measures were clinical attachment loss(CAL),probing depth(PD),plaque index(PI),calculus index(CI),bleeding on probing(BOP),and simplified oral hygiene index(OHI-S).Results A total of 16 articles were included,with a total of 1587 patients.Compared with the postmenopausal non osteoporosis group,the osteoporosis group showed significant abnormalities in CAL[standardized mean difference(SMD)=1.09,95%CI:0.62-1.57,P<0.001],PD(SMD=0.71,95%CI:0.28-1.14,P<0.001),PI(SMD=0.43,95%CI:0.29-0.56,P<0.001),and OHI-S(SMD=0.28,95%CI:0.22-0.35,P<0.001)indicators,as well as in BOP(SMD=0.01,95%CI:-0.48-0.49,P=0.97)and GI(SMD=0.01,95%CI:-0.48-0.49,P=0.97).At the level of 0.24 and 95%CI:-0.34 to 0.81,P=0.42,there was no statistically significant difference.Conclusions Women with PMOP exhibit more significant changes in indicators such as CAL,PD,PI,and OHI-S,suggesting that postmenopausal women with osteoporosis are more likely to suffer from periodontitis.