Characteristics of vascular endothelial function and its relationship with coronary artery injury in children with incomplete Kawasaki disease of different ages
Objective To explore the characteristics of endothelial function in children with incomplete Kawasaki disease(IKD)of different ages and its relationship with coronary artery lesion(CAL).Methods A total of 200 children with IKD admitted to the Affiliated Hospital of Jining Medical University from February 2020 to May 2022 were selected as the IKD group,and another 200 healthy children who underwent physical examinations during the same period were selected as the control group.According to the age of children with IKD,infants(n=78)were classified as those under 1 year old,infants(n=62)were classified as those between 1-3 years old,and preschool children(n=60)were classified as those over 3-6 years old.The endothelial function characteristics of IKD children in different age groups and normal control group children were analyzed and compared.In addition,IKD patients were divided into CAL group(n=110)and nCAL group(n=90)based on whether CAL was merged.The age,carotid intima-media thickness(IMT),flow-mediated-dilation(FMD),carotid stiffness index(SI),nitroglycerin-mediated dilation(NMD),tumor necrosis factor α(TNF-α),C-reactive protein(CRP),brachial artery endothelial dependent dilation function(EDD)and other clinical data were compared between the two groups.Cox proportional hazards model was used for univariate and multivariate analysis to identify the risk factors for CAL in IKD patients.A column chart prediction model was constructed and evaluated.Results There were statistically significant differences in FMD,NMD,SI,IMT,reactive congestion index(RHI),and EDD between IKD patients and normal control group children(all P＜0.05).There were statistically significant differences in FMD,NMD,SI,IMT,RHI,and EDD among three groups of IKD children of different ages(all P＜0.05).There were statistically significant differences in the proportion of children aged ≤3 years,TNF-α,CRP,SI,IMT,EDD,FMD,and NMD between the nCAL and CAL groups(all P＜0.05).Age ≤3 years,elevated levels of TNF-α,CRP,SI,IMT,and EDD,as well as decreased levels of FMD and NMD,were independent risk factors for CAL in children with IKD(all P＜0.05).The column chart prediction model had high discrimination,and the area under the curve for predicting CAL occurrence in children with IKD was 0.868 and 0.830,respectively.Conclusions There are significant differences in endothelial function among children with IKD of different ages,and endothelial function is closely related to the occurrence of CAL.When endothelial function is abnormal,CAL is more likely to occur.
万方数据
维普
