摘要
神经酰胺(Cer)是由细胞的质膜鞘磷脂降解产生的第二信使,是正常细胞功能所必需的脂质介质,由鞘氨醇和不同链的脂肪酸组成,且受体广泛存在于红细胞、内皮细胞、胶质细胞、免疫细胞、神经细胞上,参与氧化应激、炎症反应、信号通路传导、免疫调节等多种病理生理过程.多项研究证实Cer水平的增高与心血管疾病、2型糖尿病、脂质代谢有关,神经酰胺评分可以作为评估心血管事件严重程度及预后情况的工具.但是Cer在急性缺血性脑卒中(AIS)方面的影响研究较少.本文旨在阐述Cer的作用及其对AIS发生、发展和预后的影响.
Abstract
Ceramide(Cer)is a second messenger produced by the degradation of plasma membrane phospholipids in cells.It is an essential lipid mediator for normal cellular function,composed of sphingosine and different chains of fatty acids.Its receptors are widely present in red blood cells,endothelial cells,glial cells,immune cells,and nerve cells,and participate in various pathophysiological processes such as oxidative stress,inflammatory response,signal pathway transduction,and immune regulation.Many studies have confirmed that the increase of Cer level is related to cardiovascular disease,type 2 diabetes and lipid metabolism.Ceramide score can be used as a tool to evaluate the severity and prognosis of cardiovascular events.However,there is limited research on the impact of Cer on acute ischemic stroke(AIS).This article aims to elucidate the role of Cer and its impact on the occurrence,development,and prognosis of AIS.
基金项目
国家重点研发计划(2020YFC2006400)
海南省自然科学基金(820RC759)
海南省重点研发项目(ZDYF2021SHFZ091)
维普
万方数据