Research progress on ceramide and acute ischemic stroke
Ceramide(Cer)is a second messenger produced by the degradation of plasma membrane phospholipids in cells.It is an essential lipid mediator for normal cellular function,composed of sphingosine and different chains of fatty acids.Its receptors are widely present in red blood cells,endothelial cells,glial cells,immune cells,and nerve cells,and participate in various pathophysiological processes such as oxidative stress,inflammatory response,signal pathway transduction,and immune regulation.Many studies have confirmed that the increase of Cer level is related to cardiovascular disease,type 2 diabetes and lipid metabolism.Ceramide score can be used as a tool to evaluate the severity and prognosis of cardiovascular events.However,there is limited research on the impact of Cer on acute ischemic stroke(AIS).This article aims to elucidate the role of Cer and its impact on the occurrence,development,and prognosis of AIS.
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