Biochemical indicators of bone metabolism may change at the initial stage of type 2 diabetes,and the risk of osteoporosis and fracture in patients is significantly increased compared with normal people.Osteoporosis is a systemic bone disease characterized by low bone mass and degeneration of bone tissue microstructure,leading to increased bone fragility and susceptibility to fractures.The main mechanism of type 2 diabetes is insulin resistance(IR).A large number of clinical studies have shown that there is a relationship between insulin resistance and osteoporosis.There is a close association between miR-155 in microRNAs(miRNAs)and IR.At present,studies have found that the increased expression of miR-155 can improve insulin sensitivity,and IR is a potential mechanism leading to diabetes induced osteoporosis.However,although the risk of osteoporosis or fracture in type 2 diabetes patients increases,their bone mineral density(BMD)values are still normal or even slightly increased.Therefore,at present,the relevant mechanism of osteoporosis fracture in type 2 diabetes cannot be fully explained by BMD alone.This article mainly reviews the progress of the relationship between miR-155 and osteoporosis in type 2 diabetes patients.
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