Objective To investigate the application effect of injecting ozone water into the dorsal root ganglion combined with skin lesions in the acute stage of herpes zoster.Methods A prospective study was conducted on 90 patients with acute lesions of herpes zoster in the chest and abdomen who were admitted to the outpatient department of Changsha Central Hospital from February 2021 to April 2024.According to the random number table method,they were divided into two groups,each with 45 cases.The control group received oral administration of famciclovir,pregabalin,weak laser skin lesion illumination,and local application of mupirocin.The observation group received 10 ml of 25 μ g/ml ozone water injected into the dorsal root ganglion under ultrasound guidance on the basis of the control group,and 20 ml of 25 μg/ml ozone water injected subcutaneously into the skin lesion.Two groups of local lesions were compared in terms of the cessation of blister growth,local scab formation,and significant pain relief time.The changes in pain Numeric Rating Scale(NRS)score and the proportion of viral inclusions in the blisters during the treatment were also analyzed.The sleep quality and quality of life scores,as well as complications during the treatment process,were analyzed after 10 days of treatment in both groups.Results The observation group had a shorter time for the cessation of local lesion blister growth,local scab formation,and significant pain relief compared to the control group(all P＜0.05).After 48 hours and 10 days of treatment,the pain NRS score of both groups was lower than before treatment(all P＜0.05),and the pain NRS score of the observation group was lower than that of the control group at the same time after 48 hours and 10 days of treatment(all P＜0.05).After 48 hours and 10 days of treatment,the proportion of viral inclusions in the blisters of both groups was lower than before treatment(all P＜0.05),and the observation group had a lower proportion of viral inclusions in the blisters than the control group at the same time(all P＜0.05).After 10 days of treatment,the sleep quality and quality of life scores of the observation group were better than those of the control group(all P＜0.05).The total incidence of complications such as local infections,insomnia,palpitations,and local numbness during the treatment process of the observation group was significantly lower than that of the control group(P＜0.05).Conclusions Subcutaneous injection of ozone water into the dorsal root ganglion and lesion site of patients with acute stage herpes zoster can inhibit the growth of local blisters,promote scab formation,reduce the level of viral inclusions in blisters,effectively alleviate patient pain,improve their sleep quality and quality of life,and reduce the occurrence of complications.
Herpes zosterDorsal root ganglionSkin lesionsOzone water
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