摘要
目的 探讨不同治疗方式对消化道恶性肿瘤卵巢转移患者生存时间的影响.方法 回顾性分析湖南省肿瘤医院2008年—2018年收治的159例消化道恶性肿瘤卵巢转移患者的临床资料,根据治疗方式的不同分为5组.A组(94例):原发灶及转移灶全切+化疗;B组(13例):原发灶切除+化疗;C组(12例):仅转移灶切除;D组(17例):转移灶切除+化疗;E组(23例):原发灶及转移灶均未切除,单纯化疗.采用R语言通过Kaplan-Meier法绘制生存曲线图,并分析不同治疗方式对患者生存时间的影响.结果 159例患者中,A、B、C、D、E组患者的平均生存时间分别为26.6、23、17.3、20.3、16个月.A组与E、C+D和B组相比,生存时间分别延长了 10.6(P=0.018)、9.3(P=0.013)和3.3(P=0.003 1)个月,其余各组比较差异无统计学意义(均P＞0.05).结论 手术同时切除原发灶和转移灶并化疗的患者生存时间显著延长,仅切除转移灶并化疗的患者生存时间稍有延长,未进行手术或只切除转移灶或原发灶无助于延长患者生存时间.
Abstract
Objective To explore the effect of different treatment methods on the survival time of patients with ovarian metastasis of digestive tract malignant tumors.Methods A retrospective analysis was conducted on the clinical data of 159 patients with gastrointestinal malignant tumors and ovarian metastases admitted to Hunan Cancer Hospital from 2008 to 2018.They were divided into 5 groups according to different treatment methods.Group A(94 cases):Total resection of primary and metastatic lesions+chemotherapy;Group B(13 cases):Primary lesion resection+chemotherapy;Group C(12 cases):Only metastatic lesions were removed;Group D(17 cases):Resection of metastatic lesions+chemotherapy;Group E(23 cases):Both the primary and metastatic lesions were not removed,and chemotherapy was used alone.A survival curve was plotted using R language and Kaplan Meier method,and the impact of different treatment methods on patient survival time was analyzed.Results Among the 159 patients,the average survival time of patients in groups A,B,C,D,and E was 26.6,23,17.3,20.3,and 16 months,respectively.Compared with groups E,C+D,and B,the survival time of the group A was extended by 10.6(P=0.018),9.3(P=0.013),and 3.3(P=0.003 1)months,respectively,while there was no statistically significant difference between the other groups(all P＞0.05).Conclusions Patients who undergo surgery to simultaneously remove both primary and metastatic lesions and receive chemotherapy have significantly longer survival times,while patients who only remove metastatic lesions and receive chemotherapy have slightly longer survival times.Not undergoing surgery or only removing metastatic lesions or primary lesions does not help prolong patient survival times.
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