SGK1在消化系统疾病中的研究进展
Research progress of SGK1 in digestive system diseases
卞茜茜 1景德怀 2周广玺 2朱凤琴2
作者信息
- 1. 济宁医学院临床医学院,济宁 272067
- 2. 济宁医学院附属医院消化内科,济宁 272029
- 折叠
摘要
血清和糖皮质激素调节蛋白激酶(SGKs)是一种丝氨酸苏氨酸蛋白激酶,参与调节体内多条信号转导通路.SGKs包括SGK1、SGK2和SGK3.SGK1通过磷酸化调节炎症和免疫反应,在消化系统炎症及肿瘤等疾病的发生发展中起到至关重要的作用.本文简要介绍SGK1的结构及功能,同时描述其在消化系统疾病中的研究进展及临床意义.
Abstract
Serum and glucocorticoid-inducible kinases(SGKs)are serine threonine protein kinases involved in the regulation of multiple signal transduction pathways in vivo.SGKs include SGK1,SGK2 and SGK3.SGK1 plays a crucial role in the development of diseases such as digestive inflammation and tumors by regulating inflammatory and immune responses through phosphorylation.This article briefly introduces the structure and function of SGK1,and describes the research progress and clinical significance of SGK1 in digestive diseases.
关键词
消化系统疾病/血清和糖皮质激素调节蛋白激酶1Key words
Digestive system diseases/Serum and glucocorticoid-regulated kinase 1引用本文复制引用
出版年
2024
NETL
NSTL
万方数据