铁死亡在皮肤疾病研究中的新视角与展望
New perspectives and prospects of ferroptosis in the research of skin diseases
唐宁宁 1黄晓元 1刘洋 2李福英 2徐丹 2衷驰 2周建大2
作者信息
- 1. 湘雅常德医院整形美容科,常德 415000
- 2. 中南大学湘雅三医院整形外科,长沙 410013
- 折叠
摘要
铁死亡被认为是一种新型的、可调控的细胞死亡形式,其主要特征为铁代谢异常和脂质过氧化物的累积.尽管铁死亡在肿瘤、退行性疾病的研究中有了突破性进展,但在皮肤疾病中的研究相对较少.本文从铁死亡概念的发展出发,阐述了铁死亡的基本特征及调控机制.针对皮肤疾病领域,笔者强调了铁死亡在该领域的重要性,并详细探讨了铁死亡在各类皮肤疾病中的研究以及应用,旨在为各类皮肤疾病的治疗、临床实践提供有效指导,为未来皮肤疾病的研究方向提供新的思路.
Abstract
Ferroptosis is regarded as a novel and regulatable form of cell death,with its main characteristics being abnormal iron metabolism and the accumulation of lipid peroxides.Although there have been breakthroughs in the research of ferroptosis in tumors and degenerative diseases,its research in skin diseases is relatively scarce.Starting from the development of the concept of ferroptosis,this article expounds the basic characteristics and regulatory mechanisms of ferroptosis.In the field of skin diseases,we emphasize the importance of ferroptosis and discuss in detail the research and application of ferroptosis in various skin diseases,aiming to provide effective guidance for the treatment and clinical practice of various skin diseases,and offer new ideas for the future research direction of skin diseases.
关键词
铁死亡/皮肤疾病Key words
Ferroptosis/Skin diseases引用本文复制引用
出版年
2024
NETL
NSTL
万方数据