Analysis of clinical and electrophysiological characteristics of selective serotonin reuptake inhibitor drug-associated hypereye movement during non-rapid eye movement sleep
Objective To investigate the clinical and electrophysiological characteristics of 7 patients with non-rapid eye movement(NREM)sleep induced by selective serotonin reuptake inhibitor(SSRI).Methods The clinical and electrophysiological data of 7 patients with SSRI drug-related NREM excessive eye movement admitted to Sleep Center,Department of Neurology,the First Affiliated Hospital of Air Force Medical University,from June 2021 to May 2022 were summarized.Results Seven patients ranged in age from 10 to 76 years(median 34 years),and four were female.Four patients were diagnosed with anxiety and depression,and three patients were diagnosed with narcolepsy(one patient was comorbidized with periodic limb movement disorder).Sertraline was used in 4 patients,fluoxetine in 1 patient,escitalopram in 1 patient,and paroxetine hydrochloride in 1 patient.SSRI drug-related excessive eye movement in NREM stage was detected in all patients,which was characterized by coexistence of slow eye movement and fast eye movement,and eye movement density in stage 1 was greater than that in stage 2.All patients had sleep structure disorder,increased proportion of NREM phase 1 sleep and a large number of micro-awakenings.Conclusions During SSRI drug use,some patients have characteristic abnormal eye movement in NREM,mostly in NREM 1 and 2 sleep,which should be distinguished from normal rapid eye movement(REM)sleep.
Selective serotonin reuptake inhibitorsPolysomnographyNon-rapid eye movement stage
万方数据
维普
