Relationship between AGGF1 expression and invasion,metastasis and prognosis of hepatocellular carcinoma
Objective To detect the expression of angiogenic factor(AGGF1)with G-patch and FHA domain 1 in hepatocellular carcinoma(HCC),and to investigate its relationship with HCC angiogenesis,invasion and metastasis and its clinical significance.Methods A total of 90 primary HCC patients were selected from the Huangshi Central Hospital and Hubei Province Cancer Hospital from January 2019 to September 2020.Clinicopathological data of all patients were collected.The expression of AGGF1 and CD34 in cancer tissues of 90 HCC patients was detected by immunohistochemistry,and microvascular density(MVD)was calculated.The patients were followed up for three years.The relationship between AGGF1 and serum angiopoietin-2(Ang-2)content,MVD,clinicopathological parameters and postoperative prognosis was analyzed.Results The positive rate,relative expression level and MVD value of AGGF1 in HCC tissues were significantly higher than those in adjacent tissues(all P＜0.05).The relative expression of AGGF1 in cancer tissues was positively correlated with the MVD value(r=0.716).Serum Ang-2 content and MVD in AGGF1-positive patients were significantly higher than those in AgGF1-negative patients(all P＜0.01).AGGF1 expression in HCC tissues was significantly correlated with tumor differentiation,tumor size,(China Liver Cancer(CNLC)staging,lymph node metastasis,vascular invasion,and postoperative recurrence and metastasis(all P＜0.01).Kaplan-Meier analysis showed that the 2-and 3-year survival rates of patients with high AGGF1 expression were significantly lower than those of patients with low AGGF1 expression(all P＜0.01).Multivariate analysis showed that CNLC stage,lymph node metastasis,vascular invasion,AGGF1 expression,postoperative recurrence and metastasis were the influencing factors for postoperative survival of HCC patients(all P＜0.05).Conclusions The high expression of AGGF1 can promote the angiogenesis of HCC,and is significantly correlated with invasion and metastasis and poor prognosis,which can be a potential evaluation indicator of HCC clinical prognosis.
万方数据
维普
