Fracture is a disease caused by violence or bone disease in which the continuity of bone structure is completely or partially broken.The healing of fracture mainly includes three processes:hematoma mechanization stage,callus formation stage and callus remodeling stage.At different stages,various cells and molecules are important factors regulating fracture healing.There is growing evidence that miRNA plays an important role in various bone diseases,such as osteosarcoma,osteoarthritis,osteonecrosis,and fractures.Recent studies have shown that miRNA can regulate the process of fracture healing and may be potential biomarkers of fracture healing.This article reviews the expression,function and mechanism of miRNA in the process of fracture healing.
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