Correlation between peripheral blood T lymphocyte level and nerve function in patients with acute cerebral infarction
Objective To investigate the correlation between peripheral blood T lymphocyte level and nerve function in patients with acute cerebral infarction.Methods A total of 100 patients with acute cerebral infarction admitted to the First People's Hospital of Xianyang from May 2020 to May 2023 were selected as the observation group.According to the degree of neurological impairment,they were divided into mild injury(33 cases),moderate injury(39 cases)and severe injury(28 cases).Another 60 healthy subjects in hospital during the same period were included as the control group.The levels of peripheral blood T lymphocyte subsets,including CD3+,CD4+,CD8+,CD4+/CD8+,were detected.Spearman correlation coefficient was used to analyze the correlation between the level of peripheral blood T lymphocyte subsets and the degree of neurological impairment.Receiver operating characteristic(ROC)curve was drawn to analyze the value of T lymphocyte subsets in peripheral blood in the assessment of moderate and severe neurological impairment in acute cerebral infarction.Multivariate logistic stepwise regression was used to analyze the influencing factors of severe neurological impairment in acute cerebral infarction.Results The levels of CD3+,CD4+,CD4+/CD8+in observation group were lower than those in control group,and CD8+levels were higher than those in control group(all P＜0.05).The levels of CD3+,CD4+,CD4+/CD8+were gradually decreased and CD8+levels were gradually increased in patients with mild,moderate and severe neurological impairment(all P＜0.05).Spearman correlation analysis showed that the levels of CD3+,CD4+,CD4+/CD8+were negatively correlated with the degree of neurological impairment in patients with acute cerebral infarction,and CD8+was positively correlated with the degree of neurological impairment(all P＜0.05).According to ROC curve analysis,area under the curve(AUC)of CD3+,CD4+,CD8+and CD4+/CD8+in evaluating severe neurological impairment in acute cerebral infarction was 0.808,0.874,0.833 and 0.782,respectively,and the sensitivity was 0.791,0.821,0.806 and 0.716,respectively.The specificity was 0.758,0.818,0.788,0.727(all P＜0.05),respectively.Compared with mild defect patients,the proportion of patients with moderate and severe defect complicated with diabetes mellitus,cardioembolism in Toast classification and infarct size＞3 cm2 was higher(all P＜0.05).Multivariate logistic regression analysis showed that combined diabetes,Toast classification,infarct size,CD3+,CD4+,CD8+,CD4+/CD8+levels were the influential factors for moderate and severe neurological impairment in acute cerebral infarction(all P＜0.05).Conclusions Compared with the normal population,the levels of CD3+,CD4+,CD4+/CD8+in patients with acute cerebral infarction are lower,and the level of CD8+is higher,and the level of T lymphocytes is correlated with the degree of neurological impairment in patients,which has certain reference value for evaluating the severity of the disease.
Acute cerebral infarctionT-lymphocytesNerve function
万方数据
维普
