Distribution and drug resistance analysis of 569 neonatal infection pathogens
Objective To retrospectively analyze the distribution and drug resistance of pathogenic bacteria in neonatal infection,in order to provide evidence for rational use of antibiotics in clinic.Methods Pathogenic bacteria were collected from 497 newborn patients in the Neonatal Intensive care Unit(NICU)of the Affiliated Changsha Central Hospital,Hengyang Medical School,University of South China from January 2020 to June 2024,and the pathogen identification and drug susceptibility test were conducted.Results A total of 569 strains of pathogenic bacteria were detected,including 195 gram-positive strains(34.27％).332 Gram-negative strains(58.35％);There were 42 fungal strains,accounting for 7.38％.The top 3 gram-positive bacteria were:63 strains(11.07％),44 strains(7.73％)of Staphylococcus epidermidis and 18 strains(3.16％)of Staphylococcus aureus,all of which were sensitive to linezolid,vancomycin,tigecycline,rifampicin and amikacin(83.33％-100.00％).The top three gram negative bacteria detection rates were:Klebsiella pneumoniae,Escherichia coli,Acinetobacter baumannii.Among them,the resistance rate of Klebsiella pneumoniae to penicillins and cephalosporins was 73.33％-95.00％,the resistance rate of Escherichia coli to cotrimoxazole was the highest(71.88％),and the resistance rate of Acinetobacter baumannii to cefoxitine and cefotaxime was over 70.00％.The sensitivity of the detected fungi to amphotericin,5-fluorocytosine,voriconazole,itraconazole and fluconazole were all over 80.00％.Conclusions There are many kinds of pathogens detected in NICU in our hospital,mainly gram-negative bacteria,and the resistance rate to penicillin and cephalosporin antibiotics is high.
万方数据
维普
