Objective To investigate the correlation between serum Chemerin and nerve growth associated protein(GAP)-43 levels and hyperhomocysteinemia(HHcy)in acute ischemic stroke.Methods The clinical data of 149 patients with acute ischemic stroke admitted to the Sun Simiao Hospital of Beijing University of Traditional Chinese Medicine from March 2021 to May 2023 were retrospectively analyzed,and the patients were divided into observation group(97 cases)and control group(52 cases)according to whether they were combined with HHcy.Observation group patients were divided into mild group(n=29),moderate group(n=38)and severe group(n=30)according to the severity of the disease.The serum Chemerin and GAP-43 levels of the observation group and the control group were compared,and the serum Chemerin and GAP-43 levels of the observation group with different severity of disease were compared,and the correlation between the serum Chemerin and GAP-43 levels and the severity of acute ischemic stroke patients with HHcy was analyzed.The influencing factors of poor prognosis in patients with acute ischemic stroke complicated with HHcy were analyzed,and receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum Chemerin and GAP-43 for poor prognosis in patients with acute ischemic stroke complicated with HHcy.Results The levels of Chemerin and GAP-43 in the observation group were higher than those in the control group(all P＜0.05).Serum Chemerin and GAP-43 levels in the severe group were higher than those in the mild group and the moderate group(all P＜0.05),and serum Chemerin and GAP-43 levels in the moderate group were higher than those in the mild group(all P＜0.05).Pearson correlation analysis showed that serum Chemerin and GAP-3 levels were positively correlated with the severity of acute ischemic stroke patients with HHcy(r=0.458,0.497,all P＜0.05).Among 97 patients with acute ischemic stroke complicated with HHcy,19 had poor prognosis and 78 had good prognosis.In the poor prognosis group,the proportion of diabetes,the severity of the disease and the levels of blood glucose,C-reactive protein(CRP),vascular endothelial growth factor(VEGF)and malondialdehyde(MDA)were higher than those in the good prognosis group(all P＜0.05),and the superoxide dismutase(SOD)was lower than those in the good prognosis group(P＜0.05).Logistic regression analysis showed that the severity of the disease,CRP,Chemerin and GAP-43 were the influential factors for the poor prognosis of acute ischemic stroke patients with HHcy(all P＜0.05).ROC curve results showed that the area under the curve(AUC)of serum Chemerin and GAP-43 levels and their combination in predicting poor prognosis of acute ischemic stroke patients with HHcy were 0.799,0.804 and 0.907,respectively,and the AUC of the combination was larger(P＜0.05).Conclusions Serum Chemerin and GAP-43 levels are closely related to the severity and prognosis of acute ischemic stroke patients with HHcy,and their combined value is higher in predicting poor prognosis.
Ischemic strokeHyperhomocysteinemiaChemerinGAP-43 protein
维普
万方数据
