Objective To analyze the clinical effect of Jiawei Shengxian decoction in the treatment of acquired weakness in patients with mechanical ventilation in intensive care unit(ICU).Methods A prospective study method was used to select 68 patients with severe mechanical ventilation who met the diagnostic criteria of ICU acquired weakness(ICU-AW)and were admitted to the Department of Critical Care Medicine,Nanchong Hospital of Traditional Chinese Medicine from May 2022 to May 2023 as the study objects,and were divided into observation group and control group according to random number table method,with 34 cases in each group.The control group was treated with conventional Western medicine treatment and rehabilitation treatment,and the observation group was treated with Jiawei Shengxian decoction based on syndrome differentiation of the control group.The muscle strength indexes,symptom scores,inflammatory factors,recovery time,serum biochemical indexes and safety indexes of the two groups were evaluated and compared before and after treatment.Results Before treatment,there was no statistically significant difference in muscle strength indicators,symptom scores,inflammatory factors,and serum biochemical indicators between the two groups(all P＞0.05).After treatment,the Medical Research Council(MRC)muscle strength score,diaphragm thickness and diaphragm motion of observation group were higher than those of control group(all P＜0.05).After treatment,the scores of Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ),multiple organ failure(MODS)and traditional Chinese medicine syndrome in the observation group were lower than those in the control group,and the Barthel index(BI)score of activities of daily living in the observation group was higher than that in the control group(all P＜0.05).After treatment,the serum levels of procalcitonin(PCT),hypersensitive C-reactive protein(hs-CRP)and white blood cell count(WBC)in the observation group were lower than those in the control group(all P＜0.05).The mechanical ventilation time,ICU admission time,getting out of bed activity time and hospital stay time of the observation group were shorter than those of the control group(all P＜0.05).After treatment,the levels of hemoglobin(HGB)and platelet count(PLT)in the observation group were higher than those in the control group,and the levels of serum total bilirubin(TBIL),blood urea nitrogen(BUN)and serum creatinine(Scr)in the observation group were lower than those in control group(all P＜0.05).Conclusions Jiawei Shengxian decoction has a good effect in the adjuvant treatment of acquired asthenia in ICU patients with mechanical ventilation,which can enhance the muscle strength of limbs and the activity ability of diaphragm,improve the symptom score of patients,reduce the expression level of inflammatory factors,shorten the rehabilitation process of patients,and improve the serum biochemical indexes of patients.
J Intensive care unitsAcquired weaknessMechanical ventilationJiawei Shengxian decoction
维普
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