Objective To analyze the relationship between serum inflammatory factors and prognosis in children with severe hand,foot and mouth disease(HFMD).Methods According to the severity of the disease,100 children with HFMD-treated in the Xingtai Third Hospital from June 2022 to December 2023 were divided into severe group(38 cases)and mild group(62 cases),and 52 children admitted for physical examination during the same period were selected as the control group for retrospective analysis.Serum levels of inflammatory factors in the three groups were compared,Pearson correlation was used to analyze the relationship between the severity of the disease and the levels of inflammatory factors in the three groups,the levels of inflammatory factors in the mild group and the severe group with different prognosis after treatment were compared,and the factors affecting the prognosis of the children with HFMD were analyzed by multivariate logistic regression.Results The levels of interleukin 2,6,10,17(IL-2,IL-6,IL-10,IL-17),tumor necrosis factor-α(TNF-α),interferon-α(IFN-α),interferon-γ(IFN-γ)in the severe group before treatment[(7.89±2.04)ng/L,(59.15±14.21)ng/L,(81.54±12.54)ng/L,(59.63±12.17)ng/L,(33.74±9.55)ng/L,(91.37±23.44)ng/L,(116.48±15.77)ng/L]were higher than those in the mild and the control groups(P＜0.05).The levels of IL-2,IL-6,IL-10,IL-17,TNF-α,IFN-α and IFN-γ in the mild group[(4.77±1.12)ng/L,(28.68±8.12)ng/L,(45.41±11.28)ng/L,(36.77±10.29)ng/L,(22.45±6.68)ng/L,(68.42±15.99)ng/L,(39.58±9.45)ng/L]were higher than those in the control group(all P＜0.05).Pearson correlation analysis showed that the severity of HFMD was positively correlated with IL-2,IL-6,IL-10,IL-17,TNF-α,IFN-α and IFN-γ(all P＜0.05).After treatment,the levels of serum IL-2,IL-6,IL-10,IL-17,TNF-α,IFN-α and IFN-γ of the children with poor prognosis in the mild and severe groups were higher than those of the children with good prognosis(all P＜0.05).Logistic regression analysis showed that IL-2,IL-6,IL-10,IL-17,TNF-α,IFN-α,IFN-γ were the risk factors affecting the prognosis of children with severe HFMD(OR=2.370,1.937,2.065,2.344,2.264,2.370,2.020,all P＜0.05).Conclusions With the occurrence and aggravation of HFMD,the level of inflammatory factors in children shows an increasing trend,which is a risk factor affecting prognosis and can predict the therapeutic effect to a certain extent.
Hand,foot and mouth diseaseInflammatory cytokinesPrognosis
维普
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