LRIG——潜在的肿瘤检测新指标
LRIG,a new potential indicator of tumor detection
任杰 1李伟豪 2康强 3李松2
作者信息
- 1. 丽水市中心医院 口腔科,浙江 丽水 323000
- 2. 昆明医科大学 口腔医学院,云南 昆明 650500
- 3. 昆明医科大学 第二附属医院 肝胆外科,云南 昆明 650031
- 折叠
摘要
富亮氨酸重复序列和免疫球蛋白样结构域(leucine-rich repeats and immuno globulin-like domains, LRIG)基因家族因有相似的结构域,成为哺乳动物同源染色体上的Kekkon-1基因.其分布广泛,在真核生物和原核生物的细胞及组织中都有所表达,如脑、皮肤、耳等.LRIG属跨膜蛋白,是新发现的生长因子信号传导负调节物和肿瘤抑制物.近年的研究认为,LRIG通过与生长因子受体相互作用并增强它们的泛素化和降解来拮抗信号传导,其异常表达是肿瘤发生的重要指标.
Abstract
The Leucine-rich Repeats and ImmunoGlobulin-like domains (LRIG) gene-family are the mammalian homologs for kekkon-1 genes since they share similar domain organization. As distributed widely,LRIG expressed in eukaryotic,prokaryotic cells and tissues,such as brain,skin,ear,etc. LRIG have been identified as transmembrane proteins,newly discovered growth factor signaling negative regulators and tumor suppressors. Recent study has found that LRIG interact with growth factor receptors and enhance ubiquitination and degradation. Abnormal expression of LRIG can be an indicator of tumorigenesis.
关键词
富亮氨酸重复序列和免疫球蛋白样结构域/增殖/凋亡/表皮生长因子受体Key words
LRIG/proliferation/apoptosis/EGFR引用本文复制引用
出版年
2018
NETL
NSTL
维普
万方数据