Vorolanib is a new generation of multi-target kinase inhibitors with a completely new chemical structure.A new synthetic route to vorolanib was designed based on the existing patent synthetic route.Vorolanib was synthesized through four steps with the final yield of 55.3％and the purity of 99.01％(HPLC).The process was investigated from the aspects of raw material selection,feed ratio,reaction temperature and the optimal conditions for each step of the reaction were determined.The structures of intermediates were confirmed by 1H-NMR and ESI-MS,and the structure of vorolanib was confirmed by 1H-NMR,13C-NMR and ESI-MS.The optimized synthetic route has the advantages of simple operation,mild reaction conditions,high yield and purity,which is suitable for large-scale production,and provides a reference for the industrial production of vorolanib.
vorolanibmulti-target kinase inhibitorsynthetic process
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