Study on the synthetic process of dronedarone hydrochloride
Dronedarone hydrochloride is an approved drug for the treatment of arrhythmia.A new route to dronedarone hydrochloride was optimized on the base of references and laboratory verification.Using 5-nitrosalicylaldehyde as the starting material,the target compound was afforded by etherification,hydrolysis,cyclization,Friedel-Crafts acylation,demethylation,etherification,reduction,methane sulfonylation and salt formation,with a total yield of 44.7％and purity of 99.9％(HPLC).The improved synthetic process has the advantages of simple operation,mild reaction conditions,lower technology costs,high yield and purity,which is more suitable for industrial production.
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