Synthesis of natural saponin 3-O-(4'-O-acetyl)-α-L-arabinopyranosyloleanolic acid
The chemical synthesis of a natural oleanolic acid saponin compound 3-O-(4'-O-acetyl)-α-L-arabinopyranosyloleanolic acid was reported,which was isolated from Garcinia hanburyi Hook.f.and had good antitumor activity.The target compound was obtained by glycosidation,removal of benzoyl groups,and then by a suitable"protection"strategy,acetylation and removal of the benzyl group.A method for selective acetylation of the hydroxyl group at the 4-position of arabinose was established with high yield,which could provide a new method for the construction of selective acetylation of compounds with polyhydroxyl structure.
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