首页|黄毛榕枝叶化学成分研究

黄毛榕枝叶化学成分研究

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目的 对黄毛榕枝叶的化学成分进行系统分离纯化以及鉴定,深入挖掘我国药用植物在治疗和预防人类重大疾病方面的潜力.方法 综合利用硅胶柱色谱、ODS柱色谱、Sephadex LH-20柱色谱以及半制备HPLC等色谱分离技术,对黄毛榕枝叶的乙醇提取物进行系统分离纯化;运用核磁共振谱、低分辨质谱以及旋光等技术对分离纯化的化合物进行结构鉴定.结果与结论 从黄毛榕枝叶中共分离鉴定出17个化合物(1~17),包括两个香豆素(1和2)、两个倍半萜(3和4)、两个苯丙素(5和8)、两个黄酮类化合物(6和7)、七个三萜类化合物(9、10、13~17),以及两个甾体类化合物(11和12).所有化合物均为首次从黄毛榕中分离得到,除化合物5、9和10外,其他化合物均首次从榕属中分离得到.
Study on chemical constituents of branches and leaves of Ficus esquiroliana
In order to deeply explore the enormous potential of Chinese medicinal plants in treating and preventing major human diseases,a chemical investigation on the branches and leaves of Ficus esquiroliana was thus carried out.The ethanol extracts of this plant were systematically separated and purified by integrating silica gel column chromatography,ODS chromatography,Sephadex LH-20 chromatography,and semi-prepared HPLC.NMR,MS and optical rotation were used to identify the structures of compounds.Seventeen compounds(1-17)were isolated from F.esquiroliana,including two coumarins(1 and 2),two sesquiterpenes(3 and 4),two phenylpropanoids(5 and 8),two flavones(6 and 7),seven triterpenoids(9,10,13-17),and two sterides(11 and 12).All compounds were isolated for the first time from F.esquiroliana,and compounds 1-4,6-8,and 11-17 were isolated for the first time from the genus Ficus.

FicusFicus esquirolianachemical constituenttriterpenoidcoumarinsesquiterpeneflavone

代德财、张笑笑、徐晓娟、李子昂、董凌嫣、陈青霞、张蕊

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海南科技职业大学化学与材料工程学院,海南海口 571126

榕属 黄毛榕 化学成分 三萜 香豆素 倍半萜 黄酮

国家级大学生创新训练项目海南省大学生创新训练项目

14172S202114172029

2024

中国药物化学杂志
沈阳药科大学,中国药学会

中国药物化学杂志

CSTPCD
影响因子:0.463
ISSN:1005-0108
年,卷(期):2024.34(3)
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