Research on impurities in furosemide raw materials from different manufacturer sources
A study was conducted on the confirmation of crystal forms and impurity analysis of furosemide raw materials from different manufacturers.Using XPRD ray powder diffraction analyzer,it was confirmed that the crystal forms of furosemide raw materials from manufacture A and manufacture B were consistent with the reported crystal form Ⅰ.High-performance liquid chromatography analysis showed that there were differences in the types and contents of impurities in furosemide raw materials produced by different manufacturers,with injection-grade raw materials having relatively fewer impurities and lower contents.The research results are significant for controlling the quality of furosemide products and ensuring the safety of clinical medication use.
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万方数据
