Research progress of natural products with potential to treat gouty nephropathy
Gouty nephropathy(GN)refers to renal damage caused by hyperuricemia resulting from excessive production of uric acid in the blood or reduced excretion.Numerous studies have confirmed that hyperuricemia is an independent risk factor for chronic kidney diseases such as GN.Treatment strategies for GN involve managing hyperuricemia and safeguarding renal function.Although current clinical use of anti-gout medications effectively reduces blood uric acid levels,they often lead to severe allergic reactions and liver and kidney damage.Natural products possess a multi-target synergistic effect on lowering uric acid levels and exerting anti-inflammatory activities,while maintaining high safety profiles.Therefore,they have become an important focus in the search for new drugs against gouty nephropathy.This review aims to summarize recent research conducted over the past decade on natural products with uric acid-lowering properties and renal protection mechanisms,providing valuable references for drug development in the treatment of gouty nephropathy.
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