Research progress in antitumor inhibitors based on histone deacetylase 6
Histone deacetylase 6(HDAC6)is a member of the histone deacetylase family,which not only regulates the acetylation state of histones,but also catalyzes various nonhistone substrates,includingα-tubulin,cortactin,HSP90,HSF-1,Ku-70,and PD-L1.These substrates play important roles in the occurrence and development of tumors.Therefore,HDAC6 has become a potential target for the development of antitumor drugs.In this paper,the research progress in antitumor inhibitors based on histone deacetylase 6 was introduced,and the compounds on the basis of structure in recent years were summarized.This review will provide ideas and directions for the further research.
histone deacetylase 6small molecule inhibitorantitumor drug
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