In this study,the synthetic processs of resiquimod was improved.The target compound resiquimod was obtained via ten steps recations,including reduction,condensation,dehydration cyclization,chlorination,substitution,reduction,amidation,substitution,dehydration cyclization,N-oxidation and ammonification,with a total yield of 28.6％and a purity of 99.82％(HPLC).The structure of the target compound was confirmed by ESI-MS,1H-NMR and 13C-NMR.The improved process has the advantages of mild reaction conditions,reduced cost and convenient reaction operation,and is suitable for scale-up production.
NETL
NSTL
万方数据
