Improved synthetic procedure of the imaging agent 2-[18F]F-A-85380
2-[18F]F-A-85380 is a positron emission tomography(PET)imaging agent for the noninvasive study of a4β2 nAChRs in the brain.In this study,an improved one-pot synthetic procedure of 2-[18F]F-A-85380 was designed.With(2-trimethylammonium-3-(1-tert-butoxycarbonyl-2(S)-azetidinylmethoxy)-pyridine trifluoromethanesulfonate as starting material,the target compound was obtained by the substitution and hydrolysis.The uncorrected yield was 34％with a mean radiochemical purity of more than 95％.The improved procedure has advantages of simple operation and avoiding HPLC-equipment.It is more suitable for medical institutions production.
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