Research progress of heat shock protein 70 inhibitors
Heat shock protein 70(HSP70)is widely distributed in cells and promotes protein folding and maturation process under stress.In recent years,it has been found that HSP70 is highly expressed in a variety of malignant tumor cells,which plays the roles of inhibiting apoptosis and interfering with tumor immunity,and may become a potential target for tumor therapy.Herein,the structure and mechanism of action of HSP70 and the current research progress of HSP70 small molecule inhibitors for antitumor therapy were reviewed,and the problems and challenges faced in the current research were discussed,which could provide references for the subsequent development of HSP70 inhibitors.
heat shock protein 70small molecule inhibitorantitumor drugeutectic structure
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