Research progress of small molecule carbonic anhydrase Ⅱ inhibitors
Carbonic anhydrases(CAs)are ubiquitous zinc metalloenzymes that catalyze a very simple physiological reaction,the interconversion between carbon dioxide and the bicarbonate ion.It involves in many human physiological and pathological processes,such as human acid-base balance,glaucoma and osteoporosis.It is expected to develop new type of glaucoma medications,because of the design and synthesis of various types of new small molecule carbonic anhydrase Ⅱ inhibitors in recent years.This paper reviewed recent developments in structures,functions and inhibitors of human carbonic anhydrase Ⅱ.
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