光控PROTAC研究进展
Research progress on light-controllable PROTAC
肖文轩 1杨艳平 1于泽洋 1白俊2
作者信息
- 1. 西安医学院研究生工作部,陕西西安 710021
- 2. 陕西省人民医院肿瘤内科,陕西西安 710068
- 折叠
摘要
蛋白水解靶向嵌合体(PROTAC)作为一种小分子工具,可以选择性地诱导目标蛋白质降解,被认为是控制细胞内蛋白质水平的有力工具.然而,PROTAC潜在的脱靶效应是阻碍其临床应用的主要因素之一.最近,已经有多个课题组将光作为额外刺激来控制诱导蛋白质降解.本文作者就光控PROTAC的设计原理和研究进展进行梳理总结,并讨论了光控降解蛋白质的不足与未来发展,以期为光控PROTAC进一步研究提供参考.
Abstract
As a small molecule tool that selectively induces the degradation of target proteins,PROTAC is considered as a powerful tool for controlling intracellular protein levels.However,the potential off-target effect of PROTAC is one of the major limiting factors hindering its clinical application.Recently,several research groups have utilized light as an additional stimulus to control induced protein degradation.This paper reviews the design principles and research progress of light-controlled PROTAC,discusses the limitations and future developments of light-controlled protein degradation,aiming to provide insights for further research on light-controlled PROTAC.
关键词
蛋白水解靶向嵌合体/E3泛素连接酶/光诱导蛋白质降解/降解剂Key words
PROTAC/E3 ubiquitin-ligase/light-induced protein degradation/degrader引用本文复制引用
出版年
2024
NETL
NSTL
万方数据