宣肺败毒方治疗新冠病毒感染的中医学理论探讨及现代药理研究进展

Discussion on traditional Chinese medicine theory and modern pharmacology of Xuanfei Baidu decoction for treating novel coronavirus infection

张敬升 ¹冀祖恩 ²庞博 ¹徐英莉 ¹曹姗 ¹张宇 ¹孙绮悦 ¹孙静 ¹李舒冉 ¹张薇 ²赵荣华 ¹崔晓兰¹

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作者信息

1. 中国中医科学院中药研究所,北京 100700
2. 新疆甘草及制品研究重点实验室,新疆库尔勒 841011;新疆全安药业股份有限公司,新疆库尔勒 841011
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摘要

目的探讨宣肺败毒方治疗新型冠状病毒感染的中医学理论,归纳该方的药理实验研究进展,为扩展该方的临床应用和进一步的实验研究提供参考.方法采用理论研究与文献调研相结合的方法,探讨宣肺败毒方的中医学理论和药理学进展,归纳该方的实验研究.结果宣肺败毒方适用于湿毒郁肺的患者,宣肺败毒方可通过PD-1/IL17A、IL-6/STAT3及CXCL2/CXCR2等通路改善肺损伤,以及NF-κB通路减轻肠道疾病.结论宣肺败毒方是中药和科技结合的产物,既有充分的中医药理论支撑,亦有足够的现代药理实验研究证据支持.

Abstract

Objective To discuss the traditional Chinese medicine(TCM)theory of Xuanfei Baidu decoction in treating novel coronavirus infection,summarize the experimental study of this prescription,and provide reference for later clinical and experimental purposes.Methods Using the methods of theoretical research and literature investigation,this paper discusses and summarizes the TCM theory of Xuanfei Baidu decoction and summarizes the experimental study.Results Xuanfei Baidu decoction is suitable for patients with dampness-toxic stagnation of lung.And the PD-1/IL17A,IL-6/STAT3 and CXCL2/CXCR2 pathways were used to ameliorate lung injury and NF-κB pathway to alleviate intestinal diseases.Conclusion Xuanfei Baidu decoction is a combination of TCM and science and technology,which is supported by both TCM theory and modern experimental research evidence.

关键词

宣肺败毒方/新型冠状病毒感染/湿毒郁肺/中医学/药理

Key words

Xuanfei Baidu decoction/Coronavirus Disease 2019(COVID-19)/lung with dampness-toxic stagnation/traditional Chinese medicine/pharmacology

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基金项目

国家重点研发计划(2021YFC1712903)

中国中医科学院科技创新工程(C12021A04606)

出版年

2024

中国药物警戒

国家药品监督管理局药品评价中心（国家药品不良反应监测中心）

中国药物警戒

CSTPCD

影响因子：1.105

ISSN：1672-8629

参考文献量6

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