Objective To analyze the incidence,dominating types and related factors of adverse drug reaction(ADR)in patients at an epilepsy physician-pharmacist joint clinic and to provide evidence for individualized treatment of epilepsy.Methods A retrospective survey was conducted among patients who visited the epilepsy physician-pharmacist joint clinic in our hospital in 2020-2021.The gender and age of these patients and incidence of adverse reactions were statistically analyzed before Chi-square tests were performed on the correlations between the incidence of ADR and gender,age and combined medications.Results The incidence of ADR averaged 36.17%(251/694),which was 37.08%among male patients(142/383)and 35.05%among female ones(109/311),so the difference was of no statistical difference(χ 2=0.306,P=0.580).The incidence of ADR was 24.00%,33.88%,42.96%,and 55.10%respectively in the group aged 14 or older,in the group ages 15 to 44,in the group aged 45-64 and in the group aged 65 and older,so the difference was statistically significant(χ 2=16.226,P=0.001).The incidence of ADR in patients treated with combinations of drugs and those without was 45.00%and 26.65%,respectively,and the difference was of statistical significance(χ 2=25.279,P=0.000).Conclusion Medications for epilepsy should be individualized based on the gender,age,and combination of drugs.Patients or their family members should be reminded of the importance of regular re-examination to ensure the safety of medication.
关键词
癫痫/医师/药师/联合门诊/抗癫痫药/药品不良反应/个体化治疗
Key words
epilepsy/physician/pharmacist/joint clinic/antiepileptic drugs/adverse drug reactions/individualized treatment
维普
万方数据