Objective To evaluate the therapeutic effect of aerosol inhalation of BD-77 against mycoplasma pneumoniae(MP)infection in mice.Methods Balb/c mice were randomly divided into the normal control group,model control group,azithromycin control group(42 mg·kg-1·d-1),BD-77 high dose group(75 mg·mL-1,15 min),and BD-77 low dose group(37.5 mg·mL-1,15 min).The mouse model of mycoplasma pneumoniae pneumonia(MPP)was induced by intranasal infection with MP.After four consecutive days of aerosol inhalation,the therapeutic effect of BD-77 was evaluated based on the lung index,lung inhibition rate,and pathological changes of lung tissues.The contents of interleukin(IL)-6,IL-1β,tumor necrosis factor α(TNF-α)in lung tissues and the level of C reactive protein(CRP)in serum were also detected using ELISA method.Results Both doses of BD-77 aerosol administration could decrease the lung index and the release of IL-6,IL-1β and TNF-α in lung tissues,ameliorate pulmonary inflammation and reduce serum CRP levels.Conclusion Aerosol inhalation of BD-77 preparation is effective for MPP in mice.This study provides data for the development of BD-77 as a drug for prevention and treatment of MPP.
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