Objective To clarify the therapeutic effect of Foshao granules in mice with spastic abdominal pain,and provide basic research data support for clinical application.Methods Experimental mice were randomly divided into seven groups according to their body weight:the normal control group,model control group,Domperidone control group(12 mg·kg-1),Sini Powdered control group(3 g·kg-1),Foshao granules high dosage group(48 g crude drug·kg-1),Foshao granules middle dosage group(24 g crude drug·kg-1),Foshao granules low dosage group(12 g crude drug·kg-1),with 10 mice in each group.A cold stagnation functional abdominal painmedical syndrome combination model made by cold stimulation combined with an intraperitoneal injection of formalin.The therapeutic effect of mice with spastic abdominal pain induced by neostigmine was evaluated with the pain latency,the pain incidence,duration of pain,the pathological changes in the colon of the mice.Results The Foshao granules can significantly reduce the incidence of pain,prolong the pain incubation(P<0.05,P<0.01),shorten the pain length,and reduce the mucosal hyperplasia,and the enlargement and increase of goblet cells in the interstitial inflammation machine in the colon.Conclusion The Foshao granules significantly improved cold stimulation combined with formalin-induced functional abdominal pain in mice,providing a reference for the clinical application of Foshao granules.
维普
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